Innovative Biotech Solutions

IntelliGenome's first point of care product, our CRISPR-TB point of care (POC) blood assay, is a single test for all patient groups, designed to provide ultra-sensitive detection of Mycobacterium Tuberculosis (Mtb) DNA from nucleic acids in plasma or serum to diagnose all manifestations of pulmonary tuberculosis (PTB) and extra-pulmonary tuberculosis (EPTB) disease accurately, rapidly and affordably. 

IntelliGenome's CRISPR-TB point of care (POC) blood assay is designed to be a self-contained diagnostic solution, with simple requirements for sample collection and processing.

IntelliGenome's second point of care product, the Lab in Tube (LIT), incorporates reagents required to identify isolated cell-free DNA from patient blood samples in a single device. Lab in Tube is designed to be highly portable for use in resource constrained regions and among all patient groups, regardless of age or other complicating health conditions. A portable, reusable fluorescent signal reading device will also be available. 

The LIT has three parts: the first part contains high fidelity DNA polymerase, PCR buffer with integrated double-stranded stabilization protein, dNTP, and primer pairs of TB IS-6110 for nucleic acid amplification; the second part includes the components of the CRISPR reaction, primarily Cas enzyme, along with a reaction buffer mixed with fluorescent probes, gRNA and disposable paper strips; the third part consists of paper strips for accurate identification of TB-IS6110,  a sequence of DNA that is unique to Mtb. These components will be sold together and are disposable. Portable fluorescent readers will be sold separately for long-term use.